With Prolotherapy, an injectate is injected into the lax or torn areas causing a stress inflammation. This inflammation results in the proliferative cells migrating to the weakened area, allowing for growth of new, strengthened tissues. This is how Prolotherapy provides a mechanism by which the body can work toward healing itself.
Prolotherapy helps stimulate the body to make collagen. This is accomplished through a series of injections, not of collagen, but of a mild chemical or a natural irritant such as dextrose (sugar), which stimulates an immune response facilitating the body to produce collagen naturally. The immune response is facilitated because the procedure causes a stress inflammation (unlike that caused from an infection) and the body responds to this, thereby starting the repair process. The procedure increases the number of fibroblasts, which synthesize collagen.
The making of new collagen facilitates tissue repair, which allows for strengthened and restored tendons, ligaments and joints, and ultimately translates into more significant and/or permanent pain relief. There is no evidence that this process causes scarring in the area of the injections. The advantage of Prolotherapy is that it does not interfere with the patient’s activity level during treatment (activity can continue at work, exercise and play), and there is no postoperative recovery time.